Senior Software Engineer, Agents

About Boltz

Boltz is a public benefit company building the next generation of AI-powered molecular modeling tools to make biology programmable and accelerate drug discovery, while keeping frontier capabilities broadly accessible.

Boltz began as an MIT spin-out. Our founders built Boltz-1 at MIT, and it became the first fully open-source model to match AlphaFold 3's accuracy in predicting the 3D structure of biomolecular complexes.

We focus on two things

• Open foundation models. Boltz-1, Boltz-2, and BoltzGen are open models trusted by 100,000+ scientists across biotech and academia, and used in programs at every Top 20 pharma as well as leading agrichemical and industrial research organizations.
• Boltz Lab. Our commercial platform runs our latest models and design agents as reliable, production-grade tools built around real chemistry and biology workflows. Teams start from a target and a hypothesis, then generate, evaluate, and rank candidate molecules, while we provide the compute, infrastructure, and collaboration layer so their scientists can move faster.

The two feed each other: open-source adoption earns scientific credibility and community insight, and Boltz Lab turns that into real impact on our partners' discovery programs.

You can read more about our mission, research and product vision in our manifesto.

About the role

As a Software Engineer on Agents, you will own the design agents inside Boltz Lab: the agentic workflows that take a scientist from a target and a hypothesis to a ranked set of candidate molecules. Our goal is that scientists can set up, run, review and export protein design and small-molecule design work on their own, and agents are how much of that happens.

You will work closely with our product engineers and Product Designer, our research teams and Research Engineering, who build agent workflows on the research side, and our scientists who use the product every day.

This role is ideal for an engineer who has shipped agent-powered products to real users, knows how they fail, and cares about making them reliable and trustworthy.

What you'll do

• Build and ship agentic design workflows in Boltz Lab, for protein design and small-molecule lead optimization.
• Design the agent runtime around them: tool calling over our models and pipelines, long-running jobs, state, retries and cost control.
• Make agent behavior visible and trustworthy to scientists: what the agent did, why, and how confident it is.
• Take research agent workflows to production quickly, as part of getting new models, filters and pipelines from research into the product in under a day.
• Build evaluations and monitoring for agents in production, and feed what you learn back to Research and Product.

About you

Minimum Requirements

• Senior or Staff-level software engineering experience, with strong Python and/or TypeScript.
• Hands-on experience building and shipping LLM agent products or agentic workflows to real users.
• Solid backend and distributed-systems fundamentals: APIs, queues, long-running jobs, failure handling and observability.
• A track record of owning features end to end, from design through launch and iteration.
• Close collaboration with designers, researchers and scientists, and clear communication of trade-offs.

Preferred Requirements

• Experience evaluating agents (offline evals, production monitoring) and with current agent frameworks and model APIs.
• Exposure to computational biology, chemistry or other scientific domains; early-stage startup experience.
• Experience using Boltz models, or open-source contributions to agent tooling.

We know great people don't always tick every box. If this role excites you and you meet most of the minimum requirements, we'd like to hear from you.

What we offer

• Own the agents that leading discovery teams use to design new medicines in Boltz Lab.
• Work alongside one of the most talent-dense teams in the field.
• Significant ownership and independence, with responsibility for driving projects from concept to deployment.
• Highly competitive salary with meaningful equity in a public benefit company.
• Benefits:
• 25 days plus bank holidays a year
• Annual team offsite trip
• Private healthcare (BUPA), covering pre-existing conditions
• Pension program
• Paid parental leave
• Wellhub gym membership
• Free lunch every day
• Travel expenses

How we hire

1. Initial screen with a member of the Talent team
2. Agentic system design interview
3. Onsite in London or virtual onsite with the team
4. Offer + Onboarding

Our commitment

Boltz is committed to building a diverse team and an inclusive workplace. We welcome applicants of all backgrounds. If you need any adjustments during the hiring process, tell us at [email] and we'll make it work.